UV Synthesis Monitoring

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This exciting new development for the Activo-P11 Peptide Synthesizer enables precise automatic UV monitoring of the Fmoc removal during solid phase synthesis with feedback to the synthesizer software.

This allows the user to monitor the synthesis of peptides and to automatically change the deprotection and coupling protocols for each amino acid depending on the results.

The P11 is the first and only synthesizer on the market that uses on-line UV feedback to control coupling times, temperature and numbers of couplings. This increases the purity and reduces synthesis cost of all sequences without unnecessarily heating or double coupling amino acids that do not need to be.

New ActivoPep™ Software Release for the P11 Peptide Synthesizer - click here for details

This enables users of the P11 to synthesize longer more difficult peptides and to gather details of the conditions required to couple individual amino acids.

UV monitoring

This system works well with both DMF and NMP.

UV-NMP

Automatic UV Monitoring of ACP Synthesis
on the Activo-P11 Synthesizer - in NMP.

UV-DMF

Automatic UV Monitoring of ACP Synthesis
on the Activo-P11 Synthesizer - in DMF.

A UV monitoring method has been developed on the Activo-P11 Peptide Synthesizer that monitors the Fmoc removal and extends or changes the deprotection and coupling protocols when the deprotection is slow. Feedback control automatically programmes the addition or change to steps in the protocol or pauses the synthesizer for the user to make changes.

The UV monitoring system can be ordered with a new Activo-P11 or existing customers can be upgraded on site.