Technical Notes

Matrix Innovation has developed a new patented 100% PEG resin that offers a tremendous advantage over polystyrene resin for long and difficult peptides. With its highly crosslinked matrix it has unsurpassed mechanical and thermal stabilities. Let us present to you ChemMatrix® the 100% PEG matrix.

External surface of a ChemMatrix bead by Focused Ion Beam (FIB).

Section of a ChemMatrix bead by Focused Ion Beam (FIB).

Higher chemical stability

ChemMatrix is made exclusively from primary ether bonds which are known to be highly chemically stable. This matrix is therefore much more stable than any other commercial amphiphilic resins.

Higher loadings

The standard loadings of commercial amphiphilic resins are mainly from 0,2 up to 0,4 mmol/g. With even a better amphiphilicity ChemMatrix has loadings between 0.8 to 1.0 mmol/g, which is up to 3 times the loadings of other PEG resins.

Purer crude products

ChemMatrix resin has been compared to polystyrene resin for the synthesis of many difficult peptides and the results cleary demonstrate a huge advantage in using it. Results are shown in the following pages.

Free flowing

ChemMatrix is a user friendly resin because it is delivered as free flowing powder. It is easily weighted and transfered with minimum losses on glassware.

Higher compatibility with solvents

ChemMatrix allows the use of almost any kind of solvent, even water. The standard solvents used for polystyrene, such as dichloromethane and THF, are also very compatible with ChemMatrix Some amphiphilic resins are known to have a good swelling, but the loading and/or the mechanical stability are affected. Usually, these resins become tacky and hard to handle once solvated. You will be surprised to see how ChemMatrix is easily filtered and washed with almost any solvents.